XMRV & Other Retroviruses

New Data on Mouse Retroviruses Link to Prostate Cancer, Chronic Fatigue Syndrome

A set of studies published in the November 15, 2010 Journal of Infectious Diseases shed further light on associations between murine or mouse retroviruses and human disease. One study found xenotropic murine leukemia virus-related virus (XMRV) in normal and tumor tissue from men with prostate cancer. Two other studies in the same issue, however, did not see evidence of XMRV in people with chronic fatigue syndrome (CFS), blood-borne infections, or chronic immune suppression or activation, conflicting with prior findings. Experts urge more rigorous research and consistent methodology to help resolve such inconsistencies across studies.

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Anti-HIV Drugs Show Activity against XMRV Retrovirus Linked to Prostate Cancer and Chronic Fatigue Syndrome

The integrase inhibitor raltegravir (Isentress) and certain other antiretroviral drugs used to treat HIV are also active against xenotropic murine leukemia virus-related virus (XMRV), a distantly related retrovirus thought to play a role in prostate cancer and chronic fatigue syndrome, according to a study described in the April 1 2010? issue of the open-access journal PLoS One.

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Chronic Fatigue Syndrome Linked to Infectious Retrovirus XMRV

Two-thirds of patients with chronic fatigue syndrome were found to carry a retrovirus known as xenotropic murine leukemia virus-related virus (XMRV) in their peripheral blood cells, compared with just 4% of unaffected individuals, according to a report in the October 8, 2009 advance online edition of Science. If further research confirms that XMRV contributes to CFS, antiretroviral drugs may one day be used to treat the condition.

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