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Human Papillomavirus (HPV)

Anal Pap Screening of HIV+ Men Reveals Half Have Abnormal Cells

More than 80% of HIV positive men agreed to undergo Pap screening for anal cancer, demonstrating its feasibility, and 53% showed signs of potentially pre-cancerous abnormal cell growth.

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CROI 2011: HPV and Anal Cancer Research at CROI 2011

Human papillomavirus (HPV) infection remains common among people with HIV and anal cancer is still potentially deadly, researchers reported at CROI 2011. alt

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ICAAC 2010: Experimental Drug LMV-601 Inhibits HPV Replication and Abnormal Cell Growth in Laboratory Study

Lumavita's LMV-601, an investigational PC-PLC inhibitor, reduced expression of high-risk human papillomavirus (HPV) types 16, 18, and 31, and over time improved pre-cancerous cervical cell abnormalities in a laboratory study, researchers reported at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2010) last month in Boston.

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Gardasil HPV Vaccine Approved for Anal Cancer

On December 22, 2010, the U.S. Food and Drug Administration (FDA) approved the use of Merck's quadrivalent human papillomavirus (HPV) vaccine, Gardasil, for prevention of anal cancer in men and women age 9-26 years. The vaccine -- which targets high-risk HPV types 6, 11, 16, and 18 -- was previously approved for prevention of cervical cancer in young women.

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AIDS 2010: HPV-associated Cancer among HIV Positive Men and Women in the Combination ART Era

Precancerous anal cell changes and infection with high-risk human papillomavirus (HPV) types remain common among men with HIV despite effective antiretroviral therapy (ART) that suppresses viral load and restores CD4 cell levels, according to a study presented at the XVIII International AIDS Conference (AIDS 2010) last month in Vienna. A related study found that invasive cervical cancer -- also caused by HPV -- was associated with lower CD4 cell counts among HIV positive women in the large NA-ACCORD cohort.

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