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When to Start ART?

Very Early HIV Treatment May Delay Disease Progression, Raise CD4 Count

Starting antiretroviral therapy (ART) within the first 6 months after infection may slow immune system decline and raise CD4 T-cell counts, but the benefits may not last after treatment is stopped, according to a pair of studies published in January 17, 2013, New England Journal of Medicine.

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AIDS 2012: More People Starting HIV Treatment, Lower Viral Load in NA-ACCORD Study

More than 80% of HIV patients in the large North American ACCORD study are receiving combination antiretroviral therapy (ART), about 70% have suppressed viral load -- up from less than 50% in 2000 -- and the median age at the time of death rose by 6 years, researchers reported at the recent XIX International AIDS Conference (AIDS 2012) in Washington, DC.

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AIDS 2012: HPTN 052 Continues to Show Clinical Benefits of Earlier Antiretroviral Therapy

The HPTN 052 trial, best known for showing that early antiretroviral therapy (ART) can dramatically reduce the risk of HIV transmission within serodiscordant couples, also found that early treatment reduces the risk of clinical events and death, though the benefit was largely driven by extrapulmonary tuberculosis, researchers reported recently at the XIX International AIDS Conference (AIDS 2012) in Washington, DC.

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AIDS 2012: Incomplete CD4 T-Cell Response to ART Raises Mortality Risk

Having fewer than 700 CD4 cells/mm3 and hepatitis C coinfection were associated with greater risk of death in a study of U.S. veterans, researchers reported at the recent XIX International AIDS Conference (AIDS 2012) in Washington, DC, suggesting that it may be beneficial to start antiretroviral treatment before CD4 counts fall to this level. alt

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CROI 2012: San Francisco Early HIV Treatment Policy Linked to Lower Viral Load, Higher CD4 Count

San Francisco's policy of offering antiretroviral therapy (ART) to everyone who tests positive for HIV regardless of CD4 T-cell count has resulted in higher average CD4 counts at the time of treatment initiation and faster suppression of HIV viral load, researchers reported at the at the 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012) this month in Seattle.alt

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