Hepatitis B Topics HBV Disease Progression
EASL 2015: Prenylation Inhibitor Lonafarnib Lowers Hepatitis Delta Viral Load During Therapy
- Details
- Category: Hepatitis Delta (HDV)
- Published on Tuesday, 12 May 2015 00:00
- Written by Liz Highleyman
Lonafarnib, a farnesyl transferase inhibitor that interferes with viral assembly, reduced hepatitis delta virus (HDV) levels by more than 3 log in a Phase 2 study presented at the European Association for the Study of the Liver (EASL) 50th International Liver Congress last month in Vienna. Combining lonafarnib with pegylated interferon for 8 weeks led to significantly greater HDV RNA declines than lonafarnib alone, but boosting with ritonavir achieved an even greater effect with an all-oral regimen. HDV viral load rose again after stopping therapy, however, and researchers are now evaluating longer treatment durations.
Everolimus Did Not Improve Survival for Advanced Liver Cancer Patients
- Details
- Category: Liver Cancer/HCC
- Published on Thursday, 03 July 2014 00:00
- Written by JAMA
The mTOR inhibitor everolimus (Afinator) failed to increase overall survival for people with advanced hepatocellular carccinoma (HCC) who were previously unsuccessfully treated with sorafenib, according to results from the EVOLVE-1 trial published in the July 2 edition of JAMA.
Increased Distance Reduces Likelihood of Liver Transplant
- Details
- Category: Liver Transplant - HBV
- Published on Friday, 04 April 2014 00:00
- Written by Liz Highleyman
Living and receiving health care further away from a transplant center was associated with lower chances of being wait-listed for or receiving a liver transplant, according to a study of U.S. veterans described in the March 26 edition of JAMA.
EASL 2014: Prolonged Pegylated Interferon + Tenofovir Does Not Prevent Hepatitis Delta Relapse
- Details
- Category: Hepatitis Delta (HDV)
- Published on Friday, 18 April 2014 00:00
- Written by Liz Highleyman
Treating hepatitis B patients with hepatitis delta virus (HDV) coinfection using pegylated interferon plus tenofovir (Viread) for 96 weeks may reduce HDV viral load, but side effects are frequent and it did not significantly improve the likelihood of hepatitis B surface antigen (HBsAg) reduction, according to a report at the 49thEASL International Liver Congress last week in London.
Can Coffee Help Prevent Liver Fibrosis?
- Details
- Category: Fibrosis & Cirrhosis
- Published on Friday, 07 February 2014 00:00
- Written by Liz Highleyman
There is good evidence that coffee has a beneficial effect in people at risk for liver fibrosis and there are plausible biological mechanisms to explain why, according to an editorial in the January 27 advance online edition of Hepatology. However, the amount needed to see such an effect may be too high for many people to tolerate, they cautioned.
EASL 2014: New Research Sheds Light on Liver Cancer Diagnosis, Staging, and Treatment
- Details
- Category: Liver Cancer/HCC
- Published on Monday, 14 April 2014 00:00
- Written by EASL
Dramatic regional differences in survival rates for people with hepatocellular carcinoma (HCC) are largely attributable to varying national policies regarding screening and treatment, according to study findings presented at the 49thEASL International Liver Congress last week in London. Related research showed that percutaneous radiofrequency ablation is effective for treating single liver cancer tumors.
ILCA 2013: High HBV Viral Load Raises Risk of Progression to Liver Cancer
- Details
- Category: Liver Cancer/HCC
- Published on Friday, 04 October 2013 00:00
- Written by Liz Highleyman
Hepatitis B patients with high HBV DNA levels, indicating active viral replication, are more likely to experience progression of abnormal liver nodules to hepatocellular carcinoma, researchers reported at the 7th International Liver Cancer Association Annual Conference (ILCA 2013) last month in Washington, DC.
More Articles...
- ICAAC 2013: Liver Cancer Often Diagnosed Late with Poor Survival in People with HIV
- FDA Warns of Hepatitis B Reactivation Risk with Immune-suppressing Cancer Drugs
- Human Stem Cells Used to Create Functional Liver Cells in Mice
- DDW 2013: Does HBV Suppression Prevent Liver Disease Progression?
- Low Vitamin D Linked to Greater Hepatitis B Virus Replication
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