Hepatitis C Virus Strains Re-infect New Liver after Transplantation
Below is a media advisory from Rockefeller University Press,
publisher of the journal, describing the study and its findings.
Hepatitis C Viruses Infect Transplanted Livers?
16, 2010 -- Not all viruses are created equal. In liver transplant
patients with chronic hepatitis C virus (HCV) infection, only
viruses that can dodge the immune response invade the new liver,
according to a study published on August 16 in The Journal of
Experimental Medicine (www.jem.org).
Chronic HCV infection is the leading indication for liver transplantation
in the U.S. But installing a new liver does not cure disease;
in fact, HCV infects the transplanted liver in nearly all patients.
However, only a subset of the viruses present prior to transplantation
show up in the new organ, according to a study lead by Francoise
Stoll-Keller and Thomas Baumert at the University of Strasbourg
in France. Compared to many of their pre-transplant brethren,
the viruses that invaded the new organ infected liver cells
more readily and were impervious to the antibodies that normally
In most patients, the post-transplant viruses had mutations
in one region of the surface protein the virus uses to infect
cells. Blocking this region may thus provide a new way to prevent
reinfection after liver transplant.
About The Journal of Experimental Medicine
The Journal of Experimental Medicine (JEM) is published
by the Rockefeller University Press. All editorial decisions
on manuscripts submitted are made by active scientists in conjunction
with our in-house scientific editors. JEM content is posted
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six months after publication. Authors retain copyright of their
published works and third parties may reuse the content for
non-commercial purposes under a creative commons license. For
more information, please visit www.jem.org.
Investigator affiliation: Institut National de la Santé
et de la Recherche Médicale, Unité 748, F-67000
Strasbourg, France; Université de Strasbourg, Strasbourg,
France; Laboratoire de Virologie, Pôle des Pathologies
Digestives, Hépatiques et Transplantation, and Pôle
Hépato-digestif, Hôpitaux Universitaires de Strasbourg,
Strasbourg, France; Center for Vaccinology, Ghent University
and Hospital, 9000 Ghent, Belgium; Medical Research Council
Centre for Virus Research, University of Glasgow, Glasgow, Scotland,
UK; Institut National de la Santé et de la Recherche
Médicale, Unité 758, Institut Fédératif
de Recherche 128, Ecole Normale Supérieure, Université
Claude Bernard Lyon 1, Université de Lyon, Lyon, France.
Fafi-Kremer, I Fofana, E Soulier, and others. Viral entry and
escape from antibody-mediated neutralization influence hepatitis
C virus reinfection in liver transplantation. Journal of
Experimental Medicine (Abstract).
August 16, 2010 (Epub ahead of print).
University Press. Fittest Hepatitis C Viruses Infect Transplanted
Livers. Press release. August 16,2 010.